Basic Science

P. Everts et al. – A Comparative Quantification in Cellularity of Bone Marrow Aspirated with two New Harvesting Devices

The first aim of this study was to examine the cellularity and quality of autologous bone marrow aspirates harvested with two novel FDA-cleared devices, namely the Aspire™ bone marrow aspiration system (AS-BMAS) and the Marrow Cellution bone marrow aspiration device (MC-BMAD). Compared to traditional bone marrow harvesting needle systems, both these devices have a closed distal tip, avoiding preferential marrow collection (peripheral blood aspiration) from deeper cavity regions, whereas the side holes facilitate more horizontal marrow extraction.

Strength in diversity – A feature of MSC cultures may be a therpeutic boon worth exploring

As we discussed in my previous article, a consensus panel of markers identifying MSCs was reached in 2006 (Dominici et al. 2006) and it included parameters dictated by culturing methods of the 1960s. As a result, MSC cultures are a mixture of colonies from different founder cells. This condition has interesting implications for the manufacturing and …

Strength in diversity – A feature of MSC cultures may be a therpeutic boon worth exploring Read More »

Carbon Fibers in Biomedical Applications

Carbon fiber (CF) consists of a multitude of unique physical, chemical and biological characteristics that can be utilized and exploited for a number of diverse applications. Being light weight, high strength, and chemically stable, so they are applied in various fields including aeronautical science and space science. Investigation of applications of carbon fibers to biomaterials was started 30 or more years ago, and various products have been developed. It is used widely in imaging equipment structures to support limbs being X-rayed or treated with radiation.

Carbon fiber implants aid fixation of extremity fractures in oncology cases

Carbon fiber-reinforced polyether­therketone or CFR-PEEK implants have been used in orthopedic surgery, and spine surgery in particular, for almost 2 decades. However, the increased use of these carbon-reinforced implants has recently occurred in orthopedic traumatology, sports medicine and oncology. Carbon-reinforced implants are made of composite materials that consist of carbon fiber sheets inlayed within a …

Carbon fiber implants aid fixation of extremity fractures in oncology cases Read More »

Reproduction and Fertility: How could stem cells help?

HOW COULD STEM CELLS BE USED TO MAKE EGGS AND SPERM? For many who are unable to have a biological child, due to the absence of or faulty eggs or sperm, newspaper stories about scientists making sperm or eggs from pluripotent stem cells in the lab has the potential to be a game changer. But …

Reproduction and Fertility: How could stem cells help? Read More »

The what, when, and why of mesenchymal stromal cells

A billion-dollar industry has emerged around mesenchymal stromal cells (MSCs) fueled by their intriguing and broad-range therapeutic properties. But when and how were MSCs and their potential uses discovered? Join me in a series of posts where we follow the history of MSCs. We’ll discuss their recognition and claimed uses as therapeutic tools – both …

The what, when, and why of mesenchymal stromal cells Read More »

(Nature Biomedical Engineering) Intravital three-dimensional bioprinting

abrication of three-dimensional (3D) structures and functional tissues directly in live animals would enable minimally invasive surgical techniques for organ repair or reconstruction. Here, we show that 3D cell-laden photosensitive polymer hydrogels can be bioprinted across and within tissues of live mice, using bio-orthogonal two-photon cycloaddition and crosslinking of the polymers at wavelengths longer than 850 nm.

Choose language »