Stem cells

P. Everts et al. – A Comparative Quantification in Cellularity of Bone Marrow Aspirated with two New Harvesting Devices

The first aim of this study was to examine the cellularity and quality of autologous bone marrow aspirates harvested with two novel FDA-cleared devices, namely the Aspire™ bone marrow aspiration system (AS-BMAS) and the Marrow Cellution bone marrow aspiration device (MC-BMAD). Compared to traditional bone marrow harvesting needle systems, both these devices have a closed distal tip, avoiding preferential marrow collection (peripheral blood aspiration) from deeper cavity regions, whereas the side holes facilitate more horizontal marrow extraction.

Strength in diversity – A feature of MSC cultures may be a therpeutic boon worth exploring

As we discussed in my previous article, a consensus panel of markers identifying MSCs was reached in 2006 (Dominici et al. 2006) and it included parameters dictated by culturing methods of the 1960s. As a result, MSC cultures are a mixture of colonies from different founder cells. This condition has interesting implications for the manufacturing and …

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Reproduction and Fertility: How could stem cells help?

HOW COULD STEM CELLS BE USED TO MAKE EGGS AND SPERM? For many who are unable to have a biological child, due to the absence of or faulty eggs or sperm, newspaper stories about scientists making sperm or eggs from pluripotent stem cells in the lab has the potential to be a game changer. But …

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The what, when, and why of mesenchymal stromal cells

A billion-dollar industry has emerged around mesenchymal stromal cells (MSCs) fueled by their intriguing and broad-range therapeutic properties. But when and how were MSCs and their potential uses discovered? Join me in a series of posts where we follow the history of MSCs. We’ll discuss their recognition and claimed uses as therapeutic tools – both …

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Interview with UK prof. Peter Hollands, PhD – Consultant clinical scientist in Regenerative Medicine and Assisted reproduction

Apart from these fantastic achievements, the rest of stem cell technology has been riddled with media confusion, hype, misinformation and even scientific fraud. This results in mistrust in the stem cell world and more importantly a public conception that stem cell technology is in some way ‘dangerous’. Perhaps the biggest initial hype came from embryonic stem cells. In my opinion these have no significant future in Regenerative Medicine because of regulatory issues and also because of the fact that the number of embryonic stem cells available for therapy is relatively very small.

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