Wasim Khan

Dzihan Abazovic

United Kingdom

Wasim Khan MBChB, Dip Clin Ed, MSc, MA(Cantab), PhD, FRCS(Tr&Orth)

University Lecturer, University of Cambridge, UK

Honorary Consultant Trauma & Orthopaedic Surgeon, Addenbrooke’s Hospital, Cambridge, UK

 

Research interests

Wasim Khan is a University Lecturer and Honorary Consultant Trauma and Orthopaedic Surgeon. He has a research interest in stem cell sources, characterisation, differentiation and clinical applications. His clinical interest is in Knee injuries and disease, especially cartilage and meniscal defects. He aims to identify better ways of treating cartilage and meniscal lesions in the knee and developing cell-based treatments.

Wasim was awarded a MRC Clinical Research Training Fellowship to complete his PhD looking at chondrogenesis in MSCs under the supervision of Professor Tim Hardingham at the University of Manchester. He was awarded the Syme Medal by the Royal College of Surgeons. Wasim then completed an Orthopaedic Academic Clinical Training programme at the Royal National Orthopaedic Hospital, Stanmore and University College London, where he was a Lecturer from 2010-14 under the supervision of Professor David Marsh and Professor Tim Briggs. Wasim has completed national (Bristol and Cardiff) and international (USA, Europe and Australia) clinical and research fellowships. He has authored over 300 papers, 50 chapters and 5 books.

Key publications from 2019

Yaghmour K et al (2019). Single-Stage Revision Surgery in Infected Total Knee Arthroplasty: A PRISMA Systematic Review. Journal of Clinical Medicine, 8(2). E174.

Ranmuthu C et al (2019). Are the biological and biomechanical properties of meniscal scaffolds reflected in clinical practice? A systematic review of the literature. International Journal of Molecular Sciences. 20(3). E632.

Chisari E et al (2019). The effects of TNF-alpha inhibition on cartilage: a systematic review of preclinical studies. Osteoarthritis Cartilage.  pii: S1063-4584(19)31229-4.

To K et al (2019). Autologous adipose tissue grafting for the management of the painful scar. Cytotherapy. pii: S1465-3249(19)30844-8.

 

Full list of publications on Google Scholar

 

Videos

MSCs for cartilage repair- novel techniques to optimise chondrogenesis

Register for the Global Regenerative Congress in Dubai, 18-20 September 2020

Work Experience

PRESENT POST
Honorary Consultant in Trauma & Orthopaedics, Addenbrooke’s Hospital NHS Trust, Cambridge:
February 2016 to date
University Lecturer in Trauma & Orthopaedics, Department of Surgery, School of Clinical Medicine,
Cambridge University, Cambridge: February 2016 to date

 

HONORARY POSTS
Honorary Clinical Lecturer, UCL Division of Surgery and Interventional Science, London: February 2015-
February 2016
Honorary Clinical Lecturer, UCL Division of Surgery and Interventional Science, London: April 2010-
October 2010
Honorary Clinical Research Fellow, Department of Trauma and Orthopaedics, Stepping Hill Hospital,
Stockport: February 2004-January 2007

TRAVELLING FELLOWSHIPS AND CLINIC VISITS
BOA Zimmer Travelling Fellow: Thomas Jefferson University, Philadelphia, August 2016
For my Fellowship I spent time at the Rothman Institute, Thomas Jefferson University, Philadelphia, with
Professor Javad Parvizi. The unit provides a regional service for the treatment of bone and joint infection including
infected knee replacements. I had the opportunity to attend theatres, ward rounds and discuss interesting cases as
well as attend research meetings.
EFORT Travelling Fellowship: Dubrovnik, Osijek and Zagreb, Croatia, April 2015
Following competitive application and interview selection by the BOA, I was chosen to represent the UK as an
EFORT Travelling Fellow. The visit included attendance at the South Eastern European Forum on Orthopaedics
and Traumatology in Dubrovnik, and Department of Orthopaedic Surgery and Traumatology at University
Hospital Centre Osijek. This was followed by a visit to the Special Hospital for Orthopaedic Surgery Akromion,
Krapinske Toplice, and the Orthopaedic Speciality Hospital St. Catherine, Zabok. The Fellowship also included a
visit to Zagreb where I attended the Department of Orthopaedic Surgery at University Hospital Centre Zagreb, the
Department of Traumatology at University Hospital Centre Sestre Milosrdnice, and the Children‟s University
Hospital.
The Fellowship included lectures, workshops, departmental visits, live surgery demonstrations and interactive
discussions. I had the opportunity to scrub in a knee arthroplasty case. I also took the opportunity to learn about
healthcare and orthopaedic practice in other European countries, and learn about training, CPD and challenges
facing other European trainees. I forged clinical and research links both at the Institutions visited and with fellow
EFORTdelegates.

 

Education

MBChB, University of Manchester 1994-1999
MRCS, The Royal College of Surgeons of Edinburgh 2003
MSc Orthopaedic Engineering, University of Cardiff 2003-2006
PhD Biomolecular Sciences, University of Manchester 2004-2007 (Awarded the Syme Medal by The Royal College
of Surgeons of Edinburgh)
FRCS (Tr & Orth), The Royal College of Surgeons of England 2013
PG Dip Clinical Education, Royal College of Physicians & Surgeons of Glasgow/ eduQual 2015
CCT, Trauma & Orthopaedics, General Medical Council 2015

 

RESUME OF SCHOOL, UNDERGRADUATE AND POSTGRADUATE QUALIFICATIONS
 A-levels in Biology (A), Chemistry (B) and Physics (B) at Langley Grammar School, Langley, Berkshire, 1991-
1993.
 Six honour points in examinations and special study modules during the pre-clinical and clinical years at the
University of Manchester 1994-1999.
 Honours for the undergraduate research module project entitled, „The Use of Various Definitions for Recording
Operative Mortality by Cardiothoracic Surgical Societies‟.
 Final year elective period in Spain attached to Hospital Universitario de LaLaguna at the Department of Maxillofacial surgery. I wrote a case report on the management of Le Fort‟s fractures.
 MRCS Part 1 RCSEng November 2001, MRCS Part 2 RCSEd May 2003.
 Certificate of Completion of Basic Surgical Training April 2006.
 Average mark of 70% in coursework and examinations for the distance learning Masters degree (MSc) in
Orthopaedic Engineering at Cardiff University. MSc awarded in 2006.
 Doctorate degree (PhD) at the University of Manchester looking into the use of stem cells derived from fat pads
and synovium for cartilage repair, as a Medical Research Council (MRC) and RCSEd Clinical Research Training
Fellow. PhD awarded in 2007.
• In 2011, I was awarded the Syme Medal, a prestigious mark of excellence awarded by the RCSEd to a Fellow or
Member of the College, on the basis of my doctorate thesis.
• FRCS (Tr & Orth) Part 1 February 2012 (score 81%), FRCS (Tr & Orth) Part 2 November 2013.
• Certificate of Completion of Training (CCT) in Trauma and Orthopaedics April 2015.
CLINICAL KNOWLEDGE AND EXPERIENCE
I have recoded all surgical procedures performed in the eLogbook since 2005. I completed my academic higher
surgical training at RNOH, Stanmore in 2015 and had performed over 2,400 cases during this period surpassing all
the CCT requirements for indicative numbers and procedures for both elective and trauma surgery. In my
Fellowships, I am having a greater exposure to revision surgery and complex knee cases.
Number of procedures performed either supervised or unsupervised before starting my substantive consultant
post:
 Femoral neck fracture fixation 85
 Hemiarthroplasty femoral neck fracture 85
 Internal fixation ankle fracture 60
 Intramedullary nailing of femoral or tibial shaft fractures 55
 Application of external fixators 10
 Arthroscopic procedures 220
 TKRs 120
 Total hip replacements 100
 Revision hip or knee arthroplasty 45
During my higher surgical training from 2007 to 2015, I have also completed almost 240 work-place based
assessments including procedure-based assessments, case-based discussion, teaching assessments and multi-source
feedbacks meeting CCT requirements.
LABORATORY KNOWLEDGE AND EXPERIENCE
 Tissue handling and dissection, sectioning and staining.
 Cell isolation and culture in GLP conditions, Cell cloning.
 Magnetic and fluorescent activated cell sorting
 Cell surface characterisation of mesenchymal stem cells using cell surface staining and flow cytometry
 Chondrogenic, osteogenic and adipogenic differentiation and assays including RNA extraction, globally amplified
real-time PCR, Immunohistochemical staining, GAG and DNA assays, alkaline phosphatase enzyme activity
assays, and alizarin red and oil red O staining
 Protein extraction, Western blotting, light and fluorescence microscopy
 Gait analysis, and experience with V3D and QTM software
 Experience with murine femoral fracture external fixation models

Pubmed

PUBLICATIONS
(H-INDEX: 38, I10-INDEX: 145,
CITATIONS: 5,500)
DISSERTATIONS & THESIS
1. „Biomechanical Assessment of the Knee Joint to Determine the Optimal Management of Extensor Mechanism
Injuries‟
Dissertation submitted in partial fulfilment of MSc Orthopaedic Engineering, University of Cardiff, 2005
Supervisors: Mr DS Johnson and Professor L Nokes
2. „Investigation of the Infrapatellar Fat Pad as a Source of Stem Cells for Cartilage Repair‟
Thesis submitted in partial fulfilment of PhD Biomedical Sciences, University of Manchester, 2007
Supervisors: Professor TE Hardingham and Professor JG Andrew
MONOGRAPHS & BOOKS
1. Khan WS, Hardingham TE. Stem Cell Applications and Cartilage Tissue Engineering Approaches in
Orthopaedic Surgery. 2010, Nova Science Publishers, New York. ISBN: 978-1-60876-864-6. (Softcover
publication, 40 pages, 11 chapters).
2. Khan WS, Ravenscroft M. Patient-Completed Regional Outcome Measures in Hand Surgery. 2010, Nova
Science Publishers, New York. ISBN: 978-1-60876-685-7. (Softcover publication, 80 pages, 3 chapters).
3. Khan WS, Johnson DS. The Management of Knee Extensor Mechanism Injuries: A Biomehanical
Assessment, 2011, Lambert Academic Publishing, Saarbrücken, Germany. ISBN: 978-3-8383-4596-3.
4. Khan WS, Pastides P. Tissue Engineering and the Musculoskeletal System: A Limitless Cure? 2013, Nova
Science Publishers, New York. ISBN: 978-1-62417-067-6. (Foreword by Professor Charlie Archer)
In addition to being available as a hardback publication, the above 162 page book containing twelve chapters is
also available as an e-book ISBN: 978-1-62417-076-8.
5. Khan WS. Perioperative practice in trauma and orthopaedics. 2015, Nova Science Publishers, New York.
ISBN: 978-1-63483-325-7.
In addition to being available as a hardback publication, the above book containing 322 pages and 27 chapters
is also available as an e-book ISBN: 978-1-63483-350-9.
6. Francois K, Khan WS. EFOST Surgical Techniques in Sports Medicine- Elbow Surgery. 2015, JP Medical,
London. ISBN: 978-1-90983-639-6. (Hardback, 126 pages, 150 colour illustrations)
7. Klos B, Jones H, Kelberine F, Khan WS. EFOST Surgical Techniques in Sports Medicine- Knee Surgery:
Bone and Cartilage Vol.2. 2016, JP Medical, London. ISBN: 978-1-90983-638-9 (Hardback, 128 pages, 230
colour illustrations)
BOOK CHAPTERS
1. Four chapters in Hand Surgery: Preoperative Expectations, Techniques and Results, Editor Beckingsworth
RH, 2009, Nova Science Publishers, New York. ISBN: 978-1-60876-280-4 (hardcover) ISBN: 978-1-61209-
423-6 (e-book)
Chapter 1: Khan WS, Hardingham TE. Stem Cell Applications and Cartilage Tissue Engineering Approaches
Applicable in Hand Surgery. pp1-30.
Chapter 2: Khan WS, De Silva K, Ravenscroft M. Regional Outcome Measures in Hand Surgery. pp31-70.
Chapter 3: Rayanmarakkar F, Khan WS, Hardingham TE. Principles of Tissue Engineering Approaches for
Tendons, Skin, Nerves and Blood Vessels in the Hand. pp 71-84.
Chapter 4: Khan WS, Rayanmarakkar F, Marsh DR. Principles of Tissue Engineering Approaches for Bone
Repair in the Hand. pp 85-96.
2. Two chapters in Intensive Care Units: Stress, Procedures and Mortality Rates, Editor LeClaire SE, 2010, Nova
Science Publishers, New York. ISBN: 978-1-61728-967-5 (hardcover) ISBN: 978-1-61761-078-3 (e-book)
Chapter 10: Khan WS, Malik AA. Acute Compartment Syndrome on the Intensive Care Unit: A Life and Limb
Threatening Emergency. Pp 159-68.
Chapter 12: Chimutengwende-Gordon M, Khan WS. Blood Transfusions on the Intensive Care Unit: The
Role of Allogenous and Autologous Transfusions, and Pharmacological Agents. pp 179-88.
3. Three chgapters in Patient-Completed Regional Outcome Measures in Hand Surgery, Editors Khan WS,
Ravenscroft M, 2010, Nova Science Publishers, New York. ISBN: 978-1-60876-685-7.
Chapter 1: Questionnaires as Regional Outcome Measures. pp 1-9.
Chapter 2: Statistical Analyses of Questionnaires. pp 11-21.
Chapter 3: Regional Outcome Measures in Common Use. pp 23-63.
4. Seven chapters in Stem Cell Applications and Cartilage Tissue Engineering Approaches in Orthopaedic
Surgery, Editors Khan WS, Hardingham TE, 2010, Nova Science Publishers, New York. ISBN: 978-1-60876-
864-6.
Chapter 1: Stem Cells. pp 1-3.
Chapter 2: Sources of Adult Mesenchymal Stem Cells. pp 5-8.
Chapter 3: Differentiation of Stem Cells. pp 9-12.
Chapter 4: Stem Cell Markers. pp 13-19.
Chapter 5: Articular Cartilage. pp 21-24.
Chapter 6: Current Surgical Treatment Modalities. pp 25-27.
Chapter 7: Tissue Engineering Approaches for Articular Cartilage Defects. pp 29-31.
5. Two chapters in Advances in Medicine and Biology, Volume 27, Editor Berhardt LV, 2011, Nova Science
Publishers, New York. ISBN: 978-1-61324-068-7 (hardcover) ISBN: 978-1-62081-005-7 (e-book)
Chapter 8: Khan WS, Oragui E, Longo UG. Principles of Fracture Fixation in Orthopaedic Trauma Surgery
and Recent Advances. pp 249-60.
Chapter 11: Khan WS, Oragui E, Longo UG. Recent Developments in Total Hip Arthroplasty- Cementation,
Articulation, Minimal-Invasion and Navigation. pp 211-24.
6. Two chapters in Mesenchymal Stem Cells, Editor Xiao Y, 2011, Nova Science Publishers, New York. ISBN:
978-1-61324-669-6 (hardcover) ISBN: 978-1-62417-545-9 (e-book)
Chapter 5: Nannaparaju M, Oragui E, Khan WS. The role of stem cells, scaffolds and bioreactors in
musculoskeletal tissue engineering. pp 111-20.
Chapter 18: Oragui E, Sachinis N, Hope N, Khan WS. Short Communication: Tendon Regeneration and
Repair, and the Role of Mesenchymal Stem Cells. pp 405-12.
7. Four chapters in Advances in Medicine and Biology, Volume 30, Editor Berhardt LV, 2011, Nova Science
Publishers, New York. ISBN: 978-1-61324-381-7 (hardcover) ISBN: 978-1-62417-464-3 (e-book)
Chapter 5: Khan WS, Ravenscroft MA. Patient-Completed Questionnaires as Regional Outcome Measures. pp
73-80.
Chapter 6: Khan WS, Ravenscroft MA. The Statistical Analyses of Questionnaires: Validity, Reliability,
Responsiveness, Range and Bias. pp 81-92.
Chapter 7: Khan WS, Dheerendra S, Ravenscroft MA. The Disabilities of the Arm, Shoulder and Hand
Questionnaire and its Manchester-Modified Version. pp 93-104
Chapter 8: Khan WS, Ravenscroft MA. Patient Evaluation Measure and Michigan Hand Outcome MeasureStatistical Analyses and Practical Feasibility. pp 105-118.
8. Baring T, Khan WS, Emery R. Chapter 7: Rotator Cuff Disease: A Review of Pathophysiology and Treatment.
pp 109-20. In Advances in Medicine and Biology, Volume 36, Editor Berhardt LV, 2011, Nova Science
Publishers, New York. ISBN: 978-1-61470-702-8 (hardcover) ISBN: 978-1-61470-850-6 (e-book).
9. Al-Rashid M, Khan WS. Chapter 18: Stem cells and ligament repair. pp 341-6. In Advances in Medicine and
Biology, Volume 39, Editor Berhardt LV, 2011, Nova Science Publishers, New York. ISBN: 978-1-62100-271-
0 (hardcover) and ISBN: 978-1-62100-374-8 (e-book).
10. Two chapters in Advances in Medicine and Biology, Volume 37, Editor Berhardt LV, 2011, Nova Science
Publishers, New York. ISBN: 978-1-61470-980-0 (hardcover) ISBN: 978-1-62100-102-7 (e-book)
Chapter 11: Khan WS, Longo UG. The role of platelet rich plasma injections in Achilles tendonoses. pp 183-8.
Chapter 14: Whittingham-Jones P, Khan WS. The Use of Ceramic Bearings in Total Hip Arthroplasty and the
Management of Ceramic Component Fractures. pp 201-6.
11. Two chapters in Advances in Medicine and Biology, Volume 49, Editor Berhardt LV, 2011, Nova Science
Publishers, New York. ISBN: 978-1-61942-441-8 (hardcover) ISBN: 978-1-61942-448-7 (e-book)
Chapter 9: Rushton J, Khan WS, Bhamra J. Bone Tumours: An Overview of Pathology, Diagnosis, and
Management. pp 149-55.
Chapter 12: Dhinsa BS, Khan WS. Writing a Scientific Paper. pp 177-81.
12. Three chapters in Stem Cell Research: New Developments, Editors Tanaka H and Chang MCF, 2012, Nova
Science Publishers, New York. ISBN: 978-1-61942-081-6 (hardcover) ISBN: 978-1-61942-082-3(e-book)
Chapter 1: Rayanmarakkar F, Khan WS, Malik A, Hardingham TE. Principles of Tissue Engineering
Approaches in Plastic Surgery: Tendons and Skin. pp 1-10.
Chapter 2: Rayanmarakkar F, Khan WS, Hardingham TE. Advances in Tissue Engineering Approaches for
Neurovascular Structures. pp 11-19.
Chapter 3: Khan WS, Marsh D. Tissue Engineering Approaches for Bone Repair: Cells, Scaffolds, Growth
Factors and Gene Therapy. pp 21-32.
13. Two chapters in Athlete Performance and Injuries. Editors Bastos JH and Silva AC, 2012, Nova Science
Publishers, New York. ISBN: 978-1-61942-658-0 (hardcover) ISBN: 978-1-61942-659-7 (e-book)
Chapter 8: Tucker B, Khan WS. Evolution of the Achilles Tendon in Bipedal Locomotion: Advantages and
Flaws. pp 169-76.
Chapter 9: Yetkil A, Khan WS, Pastides P. Patellofemoral Syndrome. In Athlete Performance and Injuries. pp
177-82.
14. Three chapters in Advances in Materials Science Research, Volume 14, Editor Wythers MC, 2012, Nova
Science Publishers, New York. ISBN: 978-1-61942-937-6 (hardcover) ISBN: 978-1-61942-947-5 (e-book)
Chapter 5: Tucker B, Khan WS. Patient, Implant and Surgery Related Factors in Aseptical Loosening of Joint
Prostheses. pp 115-24.
Chapter 6: Malvankar S, Khan WS. Factors Involved in Aseptic Loosening of an Implant and its Prevention.
pp 125-34.
Chapter 8: Chaundy W, Khan WS, Pastides P. Pseudotumours. pp 151-8.
15. Five chapters in Advances in Medicine and Biology, Volume 54, Editor Berhardt LV, 2012, Nova Science
Publishers, New York. ISBN: 978-1-62081-731-5 (hardcover) ISBN: 978-1-62081-739-1 (e-book)
Chapter 7: Oragui E, Bocter D, Khan WS. The Pathomechanics and Management of Perilunate Dislocations.
pp 119-28.
Chapter 8: Oragui E, Al-Hashemi S, Laxton V, Khan WS. The Management of Flexor Tendon Injuries in
Zone 2. pp 129-38.
Chapter 9: Lau YCA, Khan WS. Literature Review in Robotic Arm-Assisted Orthopaedic Knee Arthroplasty.
pp 139-46.
Chapter 10: Ahmed A, Oragui E, Khan WS. Percutaneous Fixation of Scaphoid Fractures. pp 147-54
Chapter 11: Palmar J, Khan WS. Single-Stage Revision for Infected Total Knee Arthroplasty: A Review of the
Evidence. pp 155-60.
16. Six chapters in Stem Cells in Disease, Editor Koka PS, 2012, Nova Science Publishers, New York. ISBN: 978-
1-62257-169-7 (hardcover) ISBN: 978-1-62257-170-3 (e-book)
Chapter 15: Khan WS. Foreword: Stem Cell Applications and Tissue Engineering Approaches in Sports
Medicine – From Bench to Bedside. pp 199-206.
Chapter 16: Tucker BA, Karamsadkar SS, Khan WS, Pastides P. The Role of Bone Marrow Derived
Mesenchymal Stem Cells in Sports Injuries. pp 207-22.
Chapter 17: Newton Ede MP, Khan WS. The Challenges of Cartilage Repair and the Potential of Stem Cell
Applications. pp 223-34.
Chapter 18: Jaiswal PK, Wong K, Khan WS. Current Cell-based Strategies for Knee Cartilage Injuries. pp 235-
46
Chapter 19: Siddiqui NA, Wong JML, Khan WS, Hazlerigg A. Stem Cells for Tendon and Ligament Tissue
Engineering and Regeneration. pp 247-58
Chapter 20: Donaldson J, Khan WS, Hazlerigg A. Functional Tissue Engineering for Rotator Cuff Tendons.
pp 259-72.
17. Three chapters in Medical and Biological Frontiers Research Compendium, Editor Shartava T, 2013, Nova
Science Publishers, New York. ISBN: 978-1-62417-022-5 (hardcover) ISBN: 978-1-62417-023-2 (e-book)
Chapter 2: Khan WS, Longo UG. The role of platelet rich plasma injections in Achilles tendonoses. pp 37-42.
Chapter 3: Al-Rashid M, Khan WS. Advances in Tissue Engineering Applications for Ligament Repair. pp 43-
8.
Chapter 4: Whittingham-Jones P, Khan WS. Advances in Ceramic Bearings for Total Hip Replacement. pp 49-
54.
18. Chimutengwende-Gordon M, Khan WS. Stem cells in Ligament Tissue Engineering. In Emerging Trends in
Cell and Gene Therapy, Editors Mahato RI and Danquah M, 2012, Springer Publishers, Heidelberg, Germany.
ISBN 978-1-62703-417-3.
19. Twelve chapters in Tissue Engineering and the Musculoskeletal System: A Limitless Cure? Editors Khan WS
and Pastides P, 2012, Nova Science Publishers, New York. ISBN: 978-1-62417-067-6 (hardcover) ISBN: 978-
1-62417-076-8 (e-book)
Chapter 1: Pastides P, Khan WS. Introduction and the History of Stem Cells. pp 1-4.
Chapter 2: Khan WS, Pastides P. What are Stem Cells? pp 5-16.
Chapter 3: Pastides P, Khan WS. Modification of Stem Cells: The Effect of Scaffolds and Growth Factors.
pp17-24.
Chapter 4: Nannaparaju M, Oragui E, Khan WS. Bioreactors in Tissue Engineering. pp 25-30.
Chapter 5: Khan WS, Pastides P. Marsh DR. Tissue Engineering Approaches for Bone Repair. pp 31-46.
Chapter 6: Khan WS, Pastides P, Hardingham TE. Tissue Engineering Approaches for Cartilage Repair. pp
47-64.
Chapter 8: Pastides P, Khan WS. Tissue Engineering Approaches for Rotator Cuff Repair. pp 79-98.
Chapter 9: Pastides P, Khan WS, Nnaemeka E, Oragui E. Tissue Engineering Approaches for Meniscal
Injuries. pp 99-106.
Chapter 10: Khan WS, Pastides P, Hardingham TE. Tissue Engineering Approaches for Neurovascular
Structure. pp 107-18.
Chapter 11: Khan WS, Hardingham TE. Tissue Engineering Approaches for Skin Repair. pp 119-28.
Chapter 12: Tailor HD, Khan WS. The Effects of Ageing on Stem Cells. pp 129-36.
Chapter 13: Pastides P, Khan WS. Human Experimentation: Where are we currently? pp137-40.
20. Three chapters in Carpal Tunnel Syndrome: Risk Factors, Symptoms and Treatment Options. Editor: Morton
Ledford, 2014, Nova Science Publishers, New York. ISBN: 978-1-63321-142-1 (hardcover) ISBN: 978-1-
63321-143-8 (e-book)
Chapter 5: Khan WS, Ravenscroft MA. Patient Evaluation Measure and Michigan Hand Outcome Measure. pp
91-108.
Chapter 6: Khan WS, Ravenscroft MA. The Manchester-Modified Dash Questionnaire. pp 109-24.
Chapter 8: Khan WS, Ravenscroft MA. Patient Reported Outcome Measures in Hand Surgery. pp 137-48.
21. Nannaparaju MR, Khan WS, Vemulapall K. Chapter 7: The Biomechanics of the Ankle Joint, pp 111-8, In
Advances in Medicine and Biology, Volume 77, Editor Berhardt LV, 2014, Nova Science Publishers, New
York. ISBN: 978-1-63117-444-5 (hardcover) ISBN: 978-1-63117-445-2 (e-book).
22. Two chapters in Achilles Tendon: Biomechanics, Disorders and Clinical Implications. Editor: Adams A, 2015,
Nova Science Publishers, New York. ISBN: 978-1-63483-484-1 (hardcover) ISBN: 978-1-63483-509-1 (e-ook).
Chapter 2: Nannaparaju MR, Khan WS. The Biomechanics of Ankle Joint and its Relevance to Total Ankle
Replacement. pp 65-76.
Chapter 3: Tucker B, Khan WS. The Evolution of the Achilles Tendon. pp 77-88.
23. Two chapters in Medicine Research Summaries, Volume 5, Editors Liáng Z, ZhangB. 2015, Nova Science
Publishers, New York. ISBN: 978-1-63463-794-7 (hardcover) ISBN: 978-1-63463-893-7 (e-book).
Chapter 186: Khan WS, Oragui E, Longo UG. Recent Developments in Total Hip Arthroplasty –
Cementation, Articulation, Minimal-Invasion and Navigation
Chapter 189: Khan WS, Oragui E, Longo UG. Principles of Fracture Fixation in Orthopaedic Trauma Surgery
and Recent Advances
24. Five chapters in Medicine Research Summaries, Volume 6, Editors Liáng Z, ZhangB. 2015, Nova Science
Publishers, New York. ISBN: 978-1-63463-906-4 (hardcover) ISBN: 978-1-63463-950-7 (e-book).
Chapter 55: Nannaparaju M, Oragui E, Khan WS. The Role of Stem Cells, Scaffolds and Bioreactors in
Musculoskeletal Tissue Engineering
Chapter 68: Oragui E, Sachinis N, Hope N, Khan WS. Tendon Regeneration and Repair: The Role of Mesenchymal Stem Cells

Publications

230.Welck MJ, Hayes T, Pastides P, Khan W, Rudge B. Stress Fractures of the Foot and Ankle. Injury (in press).
PMID: 26412591 [IF 2.46]
231.Abbas A, Williams R, Khan WS, Ghandour A, Morgan-Jones R (2016). Tibial Crest Osteotomy in Extensile
Knee Exposure – a modified, low energy, suture technique. J Arthroplasty 31(2): 383-388. PMID: 26427939
[IF 2.67]
232.Mace J, Wheelton A, Khan WS, Anand S (2016). The role of bioreactors in ligament and tendon tissue
engineering. Curr Stem Cell Res Ther. 11(1): 35-40. PMID: 26337379 [IF 2.96]
233.Wheelton A, Mace J, Khan WS, Anand S (2016). Biomaterials and Fabrication to Optimise Scaffold Properties
for Musculoskeletal Tissue Engineering. Curr Stem Cell Res Ther. 11(7): 578-84. Review. PMID: 27306403 [IF
2.64]
234.Chimutengwende-Gordon M, Mbogo A, Khan WS, Wilkes R (2017) Limb Reconstruction after Traumatic
Bone Loss. Injury; 48(2): 206-213. PMID: 24332161 [IF 2.46]
235.Khan WS, Smart A (2016). Outcome of surgery for chronic patellar tendinopathy: A systematic review. Acta
Orthop Belg. 82(3): 610-26. PMID: 29119904
236.Williams RL, Khan WS, Roberts-Huntleigh N, Morgan-Jones R. Total Knee Arthroplasty in Patients with
Prior Adjacent Multi-Organism Osteomyelitis. Acta Orthop Belg. (in press)
237.Bhamra J, Bhamra K, Hindocha S, Khan WS (2017). The Role of Wrist Fusion and Wrist Arthroplasty in
Rheumatoid Arthritis. Curr Rheumatol Rev. 13(1): 23-28. PMID: 26496781
238.Walker T, Pengas Y, Khan WS (2016). A Literature Review Comparing the Results of Wrist Arthroplasty and
Wrist Fusion in Rheumatoid Patients. MOJ Orthopedics & Rheumatology, 6(5): 00239.
239.Shah P, Khan WS (2016). Revision Hip Arthroplasty in the Rheumatoid Patient. MOJ Orthopedics &
Rheumatology, 6(5): 00236.
240.Khan WS, Morgan-Jones R (2016). Debridement: defining something we all do. Journal of Trauma &
Orthopaedics, 4(1): 48-50.
241.Pengas IP, Assiotis A, Khan WS, Spalding T (2016). Adult Native Knee Extensor Mechanism Ruptures.
Injury; 47(10): 2065-70. PMID: 27423309 [IF 2.46]
242.Seyoum D, Khan WS (2016). Perioperative Considerations in Rheumatoid Patients. Curr Rheumatol Rev. 12
(3): 185-189. PMID: 27697020
243.Khozoee B, Mafi P, Mafi R, Khan W (2017). Mechanical stimulation protocols of human derived cells in
articular cartilage tissue engineering – a systematic review. Curr Stem Cell Res Ther. 12(3): 260-70. PMID:
27306401 [IF 2.64]
244.Sinclair KL, Mafi R, Mafi P, Khan W. Mesenchymal stem cells and growth factors used for bone formation,
fracture healing and non-unions- A systematic review. Curr Stem Cell Res Ther. 12(4): 312-25. PMID:
27306399 [IF 2.64]
245.Khan H, Mafi P, Mafi R, Khan W. The effects of ageing on differentiation and characterisation of human
mesenchymal stem cells. Curr Stem Cell Res Ther. (in press). PMID: 27133083 [IF 2.64]
246.Mildmay-White A, Khan W. Cell surface Markers on Adipose-Derived Stem Cells: A Systematic Review. Curr
Stem Cell Res Ther. (in press) PMID: 27133085 [IF 2.64]
247.Shaunak S, Dhinsa BS, Khan WS. The Role of 3D Modelling and Printing in Orthopaedic Tissue Engineering:
A Review of the Current Literature. Curr Stem Cell Res Ther. 2016 (in press). PMID: 27133084 [IF 2.64]
248.Lin DD, Picardo NE, Adesida A, Khan WS. Clinical Studies Using Biological and Synthetic Materials for
Meniscus Replacement. Curr Stem Cell Res Ther. (in press). PMID: 27133081 [IF 2.64]
249.Hopwood S, Khan W, Agarwal S (2016). The biplanar open wedge high tibial osteotomy preserving the tibial
tubercle. J Orthop Sci. 21(6): 786-790. PMID: 27484856
250.Khan WS, Richardson J, McCaskie A (2016). The use of stem cells in articular cartilage defects: where are we
now. Journal of Trauma & Orthopaedics, 4(3): 66-69.
251.Shaunak S, Khan WS (2016). Innovations in Trauma and Orthopaedic Surgery: 3D Printing. Journal of
Trauma & Orthopaedics, 4(3): 58-60.
252.Williams RL, Ayre WN, Khan WS, Mehta A, Morgan-Jones R (2017). Acetic Acid as Part of a Debridement
Protocol During Revision Total Knee Arthroplasty. J Arthroplasty. 32(3): 953-957. PMID: 27776909
253.Khan WS, Bhamra J, Williams R, Morgan-Jones R (2017). “Meniscal” scar as a landmark for the joint line in
revision total knee replacement. World J Orthop. 18; 8(1): 57-61. PMID: 28144580
254.Nannaparaju M, Annavaram K, Anwar R, Khan WS, Hambidge J (2017). Serial Femoral Fractures In An
Amputation Stump: A Case Report. Open Orthop J. 11: 316-320. PMID: 28567161
255.Sinclair KL, Mafi P, Mafi R, Khan WS. (2017). The Use of Growth Factors and Mesenchymal Stem Cells in
Orthopaedics: In particular, their use in Fractures and Non-Unions: A Systematic Review. Curr Stem Cell Res
Ther. 12(4): 312-25. PMID: 27306399 [IF 2.64]
256.Pengas IP, Nash W, Khan WS, Assiotis A, Banks J, McNicholas MJ (2017). Coronal Knee Alignment 40 Years
after Total Meniscectomy in Adolescents: A Prospective Cohort Study. Open Orthop J. 11: 424-431. PMID:
28660000
257.Barnett J, Ahmad MA, Khan WS, O‟Gorman A. The Diagnosis, Management and Complications Associated
with Fractures of the Talus. Open Orthop J. 11: 460-466. PMID: 28694883
258.Pillai DS, Dhinsa BS, Khan WS. Tissue Engineering in Achilles Tendon Reconstruction; the role of Stem
Cells, Growth Factors and Scaffolds. Curr Stem Cell Res Ther. 12(6): 506-12. PMID: 28545379 [IF 2.64]
259.Nancarrow-Lei R, Mafi P, Mafi R, Khan WS (2017). A Systemic Review of Adult Mesenchymal Stem Cell
Sources and Their Multilineage Differentiation Potential Relevant To Musculoskeletal Tissue Repair And
Regeneration. Curr Stem Cell Res Ther. 12(8): 601-10. PMID: 28595566 [IF 2.64]
260.Szostakowski B, Smitham P, Khan WS (2017). Plaster of Paris-Short History of Casting and Injured Limb
Immobilzation. Open Orthop J. 11: 291-296. PMID: 28567158
261.Khwaja MK, Khan WS, Ray P, Park DH (2017). A Retrospective Study Comparing Crossed and Lateral Wire
Configurations in Paediatric Supracondylar Fractures. Open Orthop J. 11: 432-438. PMID: 28660001
262.Shaikh N, Seah MKT, Khan WS (2017). Systematic review on the use of autologous matrix-induced
chondrogenesis for the repair of articular cartilage defects in patients. World J Orthop. 8(7): 588-601. PMID:
28808630
263.Malik AA, Robinson S, Khan WS, Dillon B, Lovell ME (2017). Assessment of Range of Movement, Pain and
Disability Following a Whiplash Injury. Open Orthop J. 11: 541-5. PMID: 28839498
264.Mir S, Mafi R, Mafi P, Khan WS (2018). Tissue engineering in Achilles tendon reconstruction: A systematic
review of preclinical studies. Curr Stem Cell Res Ther. 13(8): 682-690. PMID: 28891441 [IF 2.68]
265.Hodgson B, Mafi R, Mafi P, Khan WS. The Regulation of Differentiation of Mesenchymal Stem-cells into
Skeletal Muscle: A Look at Signalling Molecules Involved in Myogenesis. Curr Stem Cell Res Ther. (in press).
PMID: 28891439 [IF 2.68]
266.Khan S, Mafi P, Mafi R, Khan WS (2018). A systematic review of mesenchymal stem cells in spinal cord injury,
intervertebral disc repair and spinal fusion. Curr Stem Cell Res Ther. 13(4): 316-323. PMID: 28891440 [IF
2.68]
267.Nannaparaju M, Mortada S, Wiiks A, Khan W, Alam M (2018). Posterolateral corner injuries: Epidemiology,
anatomy, biomechanics and diagnosis. Injury, 49(6): 1024-1031. PMID: 29254623
268.Chew E, Prakash R, Khan WS (2017). Mesenchymal stem cells in human meniscal regeneration: A Systematic
Review. Ann Med Surg. 24: 3-7. PMID: 29062478
269.Killington K, Mafi R, Mafi P, Khan WS (2018). A Systematic Review of Clinical Studies Investigating
Mesenchymal Stem Cells for Fracture Non-Union and Bone Defects. Curr Stem Cell Res Ther. 13(4): 284-291.
PMID: 28914208 [IF 2.68]
270.Borakati A, Mafi R, Mafi P, Khan WS (2018). A Systematic Review and Meta-Analysis of Clinical Trials of
Mesenchymal Stem Cell Therapy for Cartilage Repair. Curr Stem Cell Res Ther. 13(3): 215-225. PMID:
28914207 [IF 2.68]
271.Riley TC, Mafi R, Mafi P, Khan WS. Knee Ligament Injury and the Clinical Application of Tissue Engineering
Techniques: A Systematic Review. Curr Stem Cell Res Ther. 13(3): 226-234. PMID: 28914209 [IF 2.68]
272.Khan W, Williams R, Hopwood S, Agarwal S (2017). Combined Intracapsular And Extracapsular Neck Of
Femur Fractures Case Series, Literature Review And Management Recommendations. Open Orthop J. 11:
600-8. PMID: 28979579
273.Bhamra JS, Dhinsa BS, Gokaraju K, Parratt T, Khan WS, Aston WA, Pollock R, Briggs TWR. Outcomes of
alveolar soft part sarcoma from a regional tumour unit. Acta Orthopaedica Belgica (in press)
274.Ardakani AHG, Khan WS (2018). The role of ageing and gender in musculoskeletal stem cell. Curr Stem Cell
Res Ther. 13(6): 432-437. PMID: 29380704 [IF 2.68]
275.Stace ET, Nagra NS, Tibrewal S, Khan WS, Carr AJ (2018). The use of novel electrospun scaffolds in
musculoskeletal tissue engineering: a focus on the rotator cuff. Curr Stem Cell Res Ther. 13(8): 619-631.
PMID: 29380705 [IF 2.68]
276.Archer DE, Mafi R, Mafi P, Khan WS (2018). Preclinical Studies on Biomaterial Scaffold use in Knee
Ligament Regeneration: A Systematic Review. Curr Stem Cell Res Ther. 13(8): 691-701. PMID: 30091417
277.Ranmuthu CDS, Ranmuthu CKI, Khan WS (2018). Evaluating the Current Literature on Treatments
Containing Adipose-Derived Stem Cells for Osteoarthritis: a Progress Update. Curr Rheumatol Rep. 20 (11):
67. PMID: 30203213 [IF 3.08]

Podium presentations

31. Khan WS. Management of Acute Compartment Syndrome and Acute Vascular Injuries. Departmental Audit
Meeting at Lister Hospital, Stevenage, Hertfordshire, 15 January 2013.
32. Khan WS. Management of Chest Trauma Patients Admitted Under Orthopaedic On-call Teams.
Departmental Audit Meeting at Lister Hospital, Stevenage, Hertfordshire, 29 April 2013.
33. Khan WS, Dhudia J, Adesida A, Hardingham TE, Marsh D, Blunn G. Optimisation of Chondrogenic
Differentiation Potential Using Clonal Mesenchymal Stem Cell Populations. The 24th Seddon Society Annual
Meeting at the RNOH, Stanmore, 16 May 2014.
34. Khwaja MK, Khan WS, Ray P, Park DH. Experience of managing supracondylar fractures in a District
General Hospital. The Joint Meeting of the Seddon Society and ABC Travelling Fellows at the RNOH,
Stanmore, 22 April 2015.
35. Hourston G, Barrett M, Khan W, Vindlachervuru M, McDonnell S. New drug, new problem- Do hip fracture
patients taking NOACs experience delayed surgery, longer hospital stay, or poorer outcomes?Cambridge
Orthopaedic Club 35th Annual Meeting, Kings College, Cambridge, 1 April 2017
36. Khan W. Optimisation of Mesenchymal Stem Cells for Cartilage Repair. ABC Fellows‟ Programme‐
Addenbrooke‟s Hospital, Cambridge, 3 May 2017
37. Challoumas D, Lloyd T, Khan WS. C

 

NATIONAL & INTERNATIONAL PODIUM PRESENTATIONS

27. Khan WS, Hardingham TE, Marsh D, Blunn G. Variation in differentiation potential in clonal mesenchymal stem cell populations. SEEFORT Conference, Dubrovnik, Croatia, 23 April 2015. 28. Williams RL, Khan WS, Williams H, Abbas A, Mehta A, Ayre WN, Morgan-Jones R. Chemical Debridement Using Acetic Acid During Revision Arthroplasty. 34th EBJIS Annual Meeting, Estoril, Portugal. 11 September 2015. 29. Williams RL, Kotwal R, Roberts-Huntley N, Khan WS, Morgan-Jones R. Patella Tendon Injuries Secondary To Cement Spacers Used At First-Stage Revision Of Infected Total Knee Replacement. 34th EBJIS Annual Meeting, Estoril, Portugal. 11 September 2015. 30. JW MacKay, TD Turmezei, J Kaggie, AR Morgan, R Janiczek, W Khan, S McDonnell, MJ Graves, GM Treece, AW McCaskie, FJ Gilbert. Ultrashort Echo Time Imaging of the Osteochondral Junction in Subjects with Knee Osteoarthritis and Age-matched Healthy Volunteers. Joint Annual Meeting ISMRM-ESMRMB, 19 June 2018 

 

INVITED PODIUM PRESENTATIONS 

10. Eldridge JD, Khan WS. How to treat early patellofemoral arthritis. International Sports Medicine and Knee Arthroplasty Meeting 2015, Gothenburg, Sweden, 29 October 2015. Talk given by Mr JD Eldridge 11. Khan WS. Stem Cells and Cartilage Repair. South West Orthopaedic Club (SWOC) Meeting, Grand Hotel, Torquay, 10 June 2016. 12. Khan WS. Clinical trials using MSCs for cartilage repair. Department of Traum & Orthopaedic Surgery, Hospital of Complimentary Medicine, Foshan, China, 20 October 2017. 13. Khan WS. Stem Cells and Cartilage Repair. 9th International Rheumatology Conference, Foshan, China, 21 October 2017. 14. Khan W. Keynote Speeh: Recent advances and developments in knee surgery: Autologous Chondrocyte Implantation, Orthopaedic 2018 International Conference, London, 9 March 2018. 15. Khan W. Plenary Speeh: The spectrum of musculoskeletal trauma and fractures: Peripros

 

INVITED NONCLINICAL PODIUM PRESENTATIONS

 Khan WS. Is BOTA Relevant Today? Programme Director‟s Forum, Quad Centre, Queen Alexandra Hospital, Plymoth, 27 January 2012. 2. Khan WS. Academic Orthopaedics: An Oxymoron?, ST3 Induction, Addenbrooke‟s Hospital, Cambridge, 13 September 2017 3. Khan WS. A career in trauma and orthopaedic surgery. Science Society Lecture at Dame Alice Owen School, Potters Bar, Hertfordshire, 23 November 2017 4. Khan WS. The use of stem cells and tissue engineering in orthopaedic surgery. Science Society Lecture at Dame Alice Owen School, Potters Bar, Hertfordshire, 23 November 2017

 

LOCAL & REGIONAL POSTER PRESENTATIONS

 8. Khan WS. Hypoxic Culture Conditions in Infrapatellar Derived Stem Cells Result in Enhanced Extracellular Matrix Deposition on Chondrogenic Differentiation. Faculty of Life Sciences (FLS) Annual Research Symposium, University of Manchester, 22 September 2006. 9. Khan WS, Jones RK, Nokes L, Johnson DS. How Accurate are Lockable Orthotic Knee Braces? – An Objective Gait Analysis Study. Stockport NHS Trust Celebration of Work Day, Stepping Hill Hospital, Stockport, 16 January 2007. 10. Hazlerigg A, Smitham P, Khan WS, Bajaj S, McCarthy I, Calder P. Defining the rattle: A mechanical study of three different types of limb reconstruction frames. The Joint Meeting of the Seddon Society and ABC Travelling Fellows at the RNOH, Stanmore, 13 May 2011. 11. Smitham P, Khan WS, Goodship A, Harrison M, Marsh D, Chenu C. The beta-blocker propanolol improves mechanical strength in rat fracture repair. The Joint Meeting of the Seddon Society and ABC Travelling Fellows at the RNOH, Stanmore, 13 May 2011. This poster was awarded the best poster presentation prize

 NATIONAL & INTERNATIONAL POSTER PRESENTATIONS

 50. Chew E, Khan WS, Agarwal S, Morgan-Jones R. Single Stage Knee Arthroplasty Revision Surgery: A Systematic Review of the Literature. 6th National Orthopaedic Infection Forum, London, UK, 24th June 2015. This poster was also presented at the UCL Acamedics Symposium on 10 October 2015 where it won the Best Postr Prize in the Surgery Section. 51. Khan WS, Williams RL, Metah A, Morgan-Jones R. SurgiHoney As A Novel Antimicrobial Coating In Salvage Revision Total Knee Arthroplasty. 34th EBJIS Annual Meeting, Estoril, Portugal, 10-12 September 2015. 52. Williams RL, Khan WS, Huntley NR, Morgan-Jones R. Total Knee Arthroplasty In Patients With Prior Adjacent Multi-Organism Osteomyelytis. 34th EBJIS Annual Meeting, Estoril, Portugal, 10-12 September 2015. 53. JW MacKay, TD Turmezei, J Kaggie, AR Morgan, R Janiczek, W Khan, S McDonnell, MJ Graves, GM Treece, AW McCaskie, FJ Gilbert. Repeatability & discrimination validity of cartilage imaging biomarkers for experimental medicine studies of knee osteoart

 

 REF STATEMENT 2013 UNIVERSITY COLLEGE LONDON 

 

1. Khan WS et al. Fat pad derived mesenchymal stem cells as a potential source of cell-based adipose tissue repair strategies. Cell Proliferation 2012; 45(2): 111-20. [IF 3.28] It is important to determine whether a potential mesenchymal stem-cell exhibits tri-lineage differentiation potential and is able to maintain its proliferation potential and cell-surface characterization on expansion in tissue culture. Our results indicate that fat pad-derived mesenchymal stem cells maintained their proliferation rate, and continued expressing mesenchymal stem-cell markers and pericyte marker 3G5 at late passages. These results also show that the cells were capable of adipogenic differentiation and thus could be a promising source for regeneration and replacement of adipose tissue in reconstructive surgery. 2. Khan WS et al. Bone Marrow Derived Mesenchymal Stem Cells Express Pericyte Markers in Culture and Show Enhanced Chondrogenesis in Hypoxic Conditions. Journal of Orthopaedic Research 2010; 8: 834-840. [IF 3.11] Bone marrow-derived mesenchymal stem cells are a potential source of cells for the repair of articular cartilage defects. Hypoxia has been shown to improve chondrogenesis in some cells. In this study, bone marrow-derived stem cells were characterized and the effects of hypoxia on chondrogenesis investigated. Pericytes are a candidate stem cell in many tissue, and our results show that bone marrow-derived mesenchymal stem cells express the pericyte marker 3G5. The response to chondrogenic culture in these cells was enhanced by lowered oxygen tension. This has important implications for tissue engineering applications of bone marrow-derived stem cells. 3. Khan WS et al. The Epitope Characterisation and the Osteogenic Differentiation Potential of Human Fat Pad Derived Stem Cells is Maintained with Ageing in Later Life. Injury 2009; 40(2): 150-157. [IF 2.46] Some clinical settings are deficient in osteogenic progenitors, e.g. atrophic nonunited fractures. These benefit from the additional use of bone marrow-derived mesenchymal stem cells, but these cells exhibit an age-related decline. In this study we showed that the fat pad is a consistent and homogenous source of stem cells that exhibits osteogenic differentiation potential with no evidence of any decline with ageing in later life. This has many potential therapeutic tissue engineering applications for the repair of bone defects in an increasingly ageing population. 4. Khan WS et al. Human infrapatellar fat pad derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2. Arthritis Research and Therapy 2008; 10(4): R74. [IF 4.27] Infrapatellar fat pad (IPFP) is a possible source of stem cells for the repair of articular cartilage defects. The effects of the expansion of these cells in fibroblast growth factor-2 (FGF-2) were tested on their proliferation, characterisation, and chondrogenic potential. We showed that 3G5-positive cells were present in perivascular regions in tissue sections of the IPFP, and proliferative adherent cells isolated from the IPFP were also 3G5- positive. These results suggest 3G5 positive pericytes as possible candidate stem cells. Our results also suggest that the expansion of these cells with FGF-2 has important consequences for facilitating their chondrogenic differentiation.

 

 

 

 

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